教研系列

王继纵

邮箱:wangjizong@pku.edu.cn

研究领域:生物大分子结构与功能

简介

个人简介

研究员、博士生导师。

 

教育经历

2011年毕业于中国海洋大学海洋生命学院,获得理学学士学位;2016年毕业于清华大学生命科学学院,获得理学博士学位;2016年7月至2019年12月在清华大学生命科学学院从事博士后工作;2020年6月加入澳门新葡萄娱乐9455。

 

研究方向

目前实验室综合利用结构生物学和生物化学等相关学科技术,研究植物光敏色素、受体激酶、抗病蛋白以及表观遗传功能复合物的分子结构与功能。之前实验室负责人在植物受体激酶和植物抗病蛋白以及抗病小体的形成、结构和功能研究方面取得重要进展,相关论文发表在Nature、Science、Structure等学术期刊。

 

 

代表性成果

1. Guozhi Bi*, Min Su*, Nan Li*, Yu Liang, Song Dang, Jiachao Xu, Meijuan Hu, Jizong Wang, Minxia Zou, Yanan Deng, Qiyu Li, Shijia Huang, Jiejie Li, Jijie Chai, Kangmin He, Yu-hang Chen, Jian-Min Zhou (2021). The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling. Cell, https://doi.org/10.1016/j.cell.2021.05.003

2. Jizong Wang, Jijie Chai (2020). Structural insights into the plant immune receptors PRRs and NLRs. Plant Physiology 182(4):1566-1581.

3. Jizong Wang, Jijie Chai (2020). Molecular actions of NLR immune receptors in plants and animals. Science China Life Sciences 63(9):1303-1316.

4. Jizong Wang*, Meijuan Hu*, Jia Wang*, Jinfeng Qi, Zhifu Han, Guoxun Wang, Yijun Qi, Hong-Wei Wang, Jian-Min Zhou, Jijie Chai (2019). Reconstitution and structure of a plant NLR resistosome conferring immunity. Science 364(6435), pii: eaav5870.

5. Jizong Wang*, Jia Wang*, Meijuan Hu*, Shan Wu, Jinfeng Qi, Guoxun Wang, Zhifu Han, Yijun Qi, Ning Gao, Hong-Wei Wang, Jian-Min Zhou, Jijie Chai (2019). Ligand-triggered allosteric ADP release primes a plant NLR complex. Science 364(6435), pii: eaav5868.

6. Jizong Wang*, Guangzhong Lin*, Rui Ma, Zhifu Han, Jijie Chai (2018). Structural insight into recognition of plant peptide hormones by plant receptor kinases. In: Hejátko J., Hakoshima T. (eds) Plant Structural Biology: Hormonal Regulations. Springer, Cham.

7. Wen Song, Zhifu Han, Jizong Wang, Guangzhong Lin, Jijie Chai (2017). Structural insights into ligand recognition and activation of plant receptor kinases. Current Opinion in Structural Biology 43: 18-27.

8. Simiao Liu*, Jizong Wang*, Zhifu Han, Xinqi Gong, Heqiao Zhang, Jijie Chai (2016). Molecular mechanism for fungal cell wall recognition by rice chitin receptor OsCEBiP. Structure 24(7): 1192-1200.

9. Wen Song*, Li Liu*, Jizong Wang, Zhen Wu, Heqiao Zhang, Jiao Tang, Guangzhong Lin, Yichuan Wang, Xing Wen, Wenyang Li, Zhifu Han, Hongwei Guo, Jijie Chai (2016). Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Research 26(6): 674-685.

10. Heqiao Zhang*, Xiaoya Lin*, Zhifu Han, Jizong Wang, Li-Jia Qu, Jijie Chai (2016). SERK family receptor-like kinases function as co-receptors with PXY for plant vascular development. Molecular Plant 9(10): 1406-1414.

11. Jizong Wang*, Hongju Li*, Zhifu Han, Heqiao Zhang, Tong Wang, Guangzhong Lin, Junbiao Chang, Weicai Yang, Jijie Chai (2015). Allosteric receptor activation by the plant peptide hormone phytosulfokine. Nature 525(7568): 265-268.

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